| Date | Day | Opponent | Location | TV | Outcome/Time |
| 02/11/2005 | Fri | Baylor | Houston, Texas (Minute Maid Park) | | L, 8-6
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| 02/12/2005 | Sat | vs. Oklahoma State | Houston, Texas (Minute Maid Park | | L, 3-2
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| 02/13/2005 | Sun | vs. Texas A&M | Houston, Texas (Minute Maid Park) | | W, 6-1
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| 02/15/2005 | Tue | $ RICE | COUGAR FIELD | | L, 7-6 (10)
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| 02/18/2005 | Fri | PEPPERDINE | COUGAR FIELD | | W, 5-3
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| 02/19/2005 | Sat | PEPPERDINE | COUGAR FIELD | | L, 6-3
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| 02/20/2005 | Sun | PEPPERDINE | COUGAR FIELD | | L, 18-12
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| 02/22/2005 | Tue | $ at Rice | Houston, Texas (Reckling Park) | | L, 4-3 (10)
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| 02/25/2005 | Fri | LSU | COUGAR FIELD | | W, 2-1
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| 02/27/2005 | Sun | LSU | COUGAR FIELD | | L, 11-5
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| 02/27/2005 | Sun | LSU | COUGAR FIELD | | L, 8-1
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| 03/04/2005 | Fri | LOYOLA MARYMOUNT | COUGAR FIELD | | L, 7-4
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| 03/05/2005 | Sat | LOYOLA MARYMOUNT | COUGAR FIELD | | W, 6-2
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| 03/06/2005 | Sun | LOYOLA MARYMOUNT | COUGAR FIELD | | W, 8-3
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| 03/08/2005 | Tue | SAM HOUSTON STATE | COUGAR FIELD | | W, 4-0
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| 03/11/2005 | Fri | at Long Beach State | Long Beach, Calif. | | W, 2-1
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| 03/12/2005 | Sat | at Long Beach State | Long Beach, Calif. | | L, 5-1
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| 03/13/2005 | Sun | at Long Beach State | Long Beach, Calif. | | L, 5-4
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| 03/18/2005 | Fri | Memphis | Memphis, Tenn. | | W, 6-0
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| 03/19/2005 | Sat | Memphis | Memphis, Tenn. | | L, 9-6
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| 03/20/2005 | Sun | Memphis | Memphis, Tenn. | | W, 11-1
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| 03/22/2005 | Tue | TEXAS A&M | COUGAR FIELD | | W, 9-6
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| 03/25/2005 | Fri | * UAB | COUGAR FIELD | | W, 9-6
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| 03/26/2005 | Sat | * UAB | COUGAR FIELD | | L, 4-7
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| 03/27/2005 | Sun | * UAB | COUGAR FIELD | | W, 8-1
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| 03/29/2005 | Tue | $ RICE | COUGAR FIELD | | L, 6-2
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| 04/02/2005 | Sat | * at Cincinnati | Cincinnati, Ohio | | L, 2-1
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| 04/03/2005 | Sun | * at Cincinnati | Cincinnati, Ohio | | W, 14-1
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| 04/05/2005 | Tue | Baylor | Waco, Texas | | W, 9-3
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| 04/08/2005 | Fri | * LOUISVILLE | COUGAR FIELD | | W, 5-1
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| 04/09/2005 | Sat | * LOUISVILLE | COUGAR FIELD | | L, 3-2
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| 04/10/2005 | Sun | * LOUISVILLE | COUGAR FIELD | | L, 10-6
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| 04/15/2005 | Fri | * at Tulane | New Orleans, La. | | W, 6-4
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| 04/16/2005 | Sat | * at Tulane | New Orleans, La. | | L, 5-4
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| 04/17/2005 | Sun | * at Tulane | New Orleans, La. | | L, 7-2
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| 04/19/2005 | Tue | at Sam Houston State | Huntsville, Texas | | W, 6-2
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| 04/22/2005 | Fri | * USF | COUGAR FIELD | | L, 6-2
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| 04/23/2005 | Sat | * USF | COUGAR FIELD | | W, 8-2
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| 04/24/2005 | Sun | * USF | COUGAR FIELD | | W, 3-2
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| 04/26/2005 | Tue | $ at Rice | Houston (Reckling Park) | | L, 10-9
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| 04/29/2005 | Fri | * at TCU | Fort Worth, Texas | | L, 7-2
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| 04/30/2005 | Sat | * at TCU | Fort Worth, Texas | | L, 9-6
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| 05/01/2005 | Sun | * at TCU | Fort Worth, Texas | | W, 6-1
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| 05/03/2005 | Tue | TEXAS SOUTHERN | COUGAR FIELD | | W, 6-5
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| 05/06/2005 | Fri | * SAINT LOUIS | COUGAR FIELD | | W, 8-6
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| 05/07/2005 | Sat | * SAINT LOUIS | COUGAR FIELD | | W, 2-1
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| 05/08/2005 | Sun | Saint Louis | COUGAR FIELD | | W, 8-2
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| 05/10/2005 | Tue | at Texas A&M | College Station, Texas | ESPN 2 | L, 7-6
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| 05/13/2005 | Fri | * at Charlotte | Charlotte, N.C. | | W, 7-5
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| 05/14/2005 | Sat | * at Charlotte | Charlotte, N.C. | | L, 8-7
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| 05/15/2005 | Sun | * at Charlotte | Charlotte, N.C. | | W, 6-5
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| 05/17/2005 | Tue | $ RICE | COUGAR FIELD | | W, 3-2
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| 05/19/2005 | Thu | * SOUTHERN MISS | COUGAR FIELD | | L, 10-5
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| 05/20/2005 | Fri | * SOUTHERN MISS | COUGAR FIELD | | W, 11-7
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| 05/21/2005 | Sat | * SOUTHERN MISS | COUGAR FIELD | | L, 11-7
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| 05/25/2005 | Wed | vs. East Carolina (at C-USA Tournament) | Hattiesburg, Miss. | | L, 6-5
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| 05/26/2005 | Thu | vs. UAB (at C-USA Tournament) | Hattiesburg, Miss. | | W, 7-5
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| 05/27/2005 | Fri | vs. East Carolina (at C-USA Tournament) | Hattiesburg, Miss. | | W, 6-4
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| 05/28/2005 | Sat | vs. Tulane (at C-USA Tournament) | Hattiesburg, Miss. | | L, 10-1
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