HOUSTON (AP) Duke Catalon scored three touchdowns and Houston's defense hurried and harassed Heisman favorite Lamar Jackson all night to propel the Cougars to a stunning 36-10 victory Thursday night that dashed No. 3 Louisville's playoff hopes.
Louisville (9-2) entered the game ranked fifth in the College Football Playoff rankings, but was outdone by Houston.
Things went wrong quickly for the mistake-prone Cardinals when they fumbled the opening kickoff to Houston (9-2). Greg Ward threw his first touchdown pass on the next play to make it 7-0. Brandon Radcliff lost a fumble later in the first and Houston added a field goal on the ensuing drive to make it 10-0.
Jackson threw for 211 yards and a touchdown, but it didn't come until the second half.
Houston then scored touchdowns on three straight possessions in the second quarter to push the lead to 31-0 at halftime. Catalon caught a touchdown pass, ran for another score and Houston got the third score in that span on a 50-yard pass by receiver Linell Bonner after a lateral.
"We were banged up. We were beat up. We were tired. We were exhausted in the month of October," Houston coach Tom Herman said. "That's not an excuse. That's reality. And our guys fought through it and they fought through that adversity and they never wavered ... and when you get the band back together and you get everybody healthy and everybody fresh and everybody doing their job ... we can play with anybody in the country. And we proved that again tonight."
Louisville opened the second half with a 12-yard touchdown pass by Jackson, but he fumbled in the red zone on the next possession to ruin a chance to close the gap.
The Cougars were in Jackson's face constantly, sacking him a season-high 11 times and keeping him from hurting them with his feet. He ran for a season-low 33 yards after piling up 338 yards rushing combined in the last two games.
After Jackson was sacked for the 10th time he threw up his hands and two of his lineman looked to be yelling at each other about who was to blame for his latest takedown.
But the Cougars weren't done getting after him just yet. On the next penalty he threw the ball away while under heavy pressure from Tyus Bowser and was flagged for intentional grounding, giving the Cougars a safety.
The Cardinals set a season-high with 15 penalties, punted a season-high six times by halftime and the 11 sacks they allowed were more than double their previous season-high. It's the fewest points they've scored since a loss at North Carolina in 2011.
Ward threw for 233 yards and two touchdowns to help the Cougars to the victory that left Cougar fans storming the field to celebrate.
LOUISVILLE: The Cardinals wrap up the regular season with a rivalry game against Kentucky next Saturday.
HOUSTON: The Cougars travel to Memphis on Friday for their regular-season finale.